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Merck
CN

365251

Sigma-Aldrich

Gö 6983

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes.

别名:

Gö 6983

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关于此项目

经验公式（希尔记法）:
C26H26N4O3
CAS Number:
133053-19-7
分子量:
442.51
MDL编号:
MFCD04040031
UNSPSC代码:
12352200
NACRES:
NA.77

主要文件

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质量水平

100

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

orange-red

溶解性

DMSO: 100 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([n](c2)CCCN(C)C)ccc(c3)OC

InChI

1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

InChI key

LLJJDLHGZUOMQP-UHFFFAOYSA-N

相关类别

一般描述

一种有效、细胞可渗透、可逆和ATP竞争性的蛋白激酶C（PKC）抑制剂，可抑制几种PKC同工酶（PKCα和PKCβ的IC50=7 nM；PKCγ的IC50=6 nM；PKCδ的IC50=10 nM；PKCζ的IC50=60 nM）。Gö 6983不能有效抑制PKCµ（IC50 = 20 µM），因此可用于区分PKCµ 与其他PKC同工酶。
一种有效、细胞可渗透的蛋白激酶C（PKC）抑制剂，已被证明可选择性抑制几种PKC同工酶（PKCα和PKCβ的IC50=7 nM；PKCγ的IC50=6 nM；PKCδ的IC50=10 nM；PKCζ的IC50=60 nM）。Gö 6983不能有效抑制PKCµ（IC50 = 20 µM），因此可用于区分PKCµ与其他PKC同工酶。

生化/生理作用

主要靶标
PKCα 和PKCβ
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：7 nM，对于PKCα 和PKCβ，6 nM，对于PKCγ；10 nM，对于PKCδ；60 nM，对于PKCζ

其他说明

Wang, D., et al. 1998.J. Biol. Chem. 273, 33027.
Stempka, L., et al. 1997.J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996.FEBS Lett.392, 77.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

毒性：标准处理（A）

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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