Gö 7874, Hydrochloride

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC₅₀ = 4 nM for rat brain PKC). Inhibits protein kinase A (IC₅₀ = 510 nM), protein kinase G (IC₅₀ = 4.8 µM), and myosin light chain kinase (IC₅₀ = 120 nM) at much higher concentrations.

Cell permeable: yes

Primary Target
PKC

Product competes with ATP.

Reversible: yes

Target IC₅₀: 4 nM against rat brain PKC

Toxicity: Standard Handling (A)

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Kleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett.5, 55.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany