产品名称
颗粒酶B抑制剂I, The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
off-white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主要靶标
颗粒酶B
颗粒酶B
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：300 nM，针对片段化蛋白2引起的淋巴细胞凋亡相关DNA片段化
Disclaimer
毒性：标准处理（A）
General description
人和鼠丝氨酸蛋白酶颗粒酶B的弱抑制剂。还通过片段化蛋白2（一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶）抑制淋巴细胞中与凋亡相关的DNA片段化（ID50=300 nM）。
人和鼠颗粒酶B的弱抑制剂。还通过片段化蛋白2（一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶）抑制淋巴细胞中与凋亡相关的DNA片段化（ID50=300 nM）。
Other Notes
Gong, B., et al. 1999.Cell Growth Different.10, 491.
Shi, L., et al. 1992.J. Exp.Med. 176, 1521.
Odake, S., et al. 1991.Biochemistry30, 2217.
Shi, L., et al. 1992.J. Exp.Med. 176, 1521.
Odake, S., et al. 1991.Biochemistry30, 2217.
Z-Ala-Ala-Asp-CH₂Cl
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Ning-Ning Ji et al.
Frontiers in neurology, 10, 1306-1306 (2020-01-11)
Hippocampal neuronal apoptosis is a devastating consequence of cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR). In this study, we assessed the contribution of cytotoxic T lymphocyte (CTL)-derived toxic mediator granzyme B (Gra-b) to the hippocampal neuronal apoptosis following CA/CPR
Yan Su et al.
Cell discovery, 8(1), 35-35 (2022-04-20)
Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led to the death of the host tumor cells, but not
Ganta Vijay Chaitanya et al.
Brain pathology (Zurich, Switzerland), 21(1), 16-30 (2010-09-10)
Infiltration of leukocytes into post-ischemic cerebrum is a well-described phenomenon in stroke injury. Because CD-8(+) T-lymphocytes secrete cytotoxic proteases, including granzyme-b (Gra-b) that exacerbates post-ischemic brain damage, we investigated roles of Gra-b in human stroke. To study the role of
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