369075
Guanidine Hydrochloride
ULTROL® Grade, ≥99% (titration), protein denaturant for purification of proteins, nucleic acids, and mRNA
别名:
Guanidinium chloride
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关于此项目
经验公式（希尔记法）:
CH5N3 · xHCl
化学文摘社编号:
分子量:
59.07 (free base basis)
UNSPSC Code:
12352107
NACRES:
NA.25
MDL number:
SMILES string
[Cl-].[N+H3]\C(=N\[H])\N
InChI
1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
InChI key
PJJJBBJSCAKJQF-UHFFFAOYSA-N
description
Merck USA index - 14, 4562
assay
≥99% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
ethanol: soluble, water: soluble
shipped in
ambient
storage temp.
15-25°C
Quality Level
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Application
- Revealing the Roles of Guanidine Hydrochloride Ionic Liquid in Ion Inhibition and Defects Passivation for Efficient and Stable Perovskites Solar Cells: Discusses how guanidine hydrochloride ionic liquid enhances the efficiency and stability of perovskite solar cells by ion inhibition and defect passivation (Saeed A et al., 2024).
- N-Fluorosulfonyl Guanidine: An Entry to N-Guanyl Sulfamides and Sulfamates: Investigates the use of N-fluorosulfonyl guanidine for synthesizing N-guanyl sulfamides and sulfamates, showcasing its potential in chemical synthesis and material science (Wang W et al., 2024).
- Efficient extraction of lignin from moso bamboo by microwave-assisted ternary deep eutectic solvent pretreatment for enhanced enzymatic hydrolysis: Explores the role of guanidine hydrochloride in enhancing the enzymatic hydrolysis of lignin extracted from moso bamboo using a microwave-assisted deep eutectic solvent method (Feng Y et al., 2024).
- Computational Enzyme Redesign Enhances Tolerance to Denaturants for Peptide C-Terminal Amidation: Details how computational redesign of enzymes, involving guanidine hydrochloride, can enhance their tolerance to denaturants, improving the efficiency of peptide C-terminal amidation processes (Zhu T et al., 2024).
- Parasite Burden of Trypanosoma cruzi in Whole Blood and Buffy Coat Determined by Real-Time PCR in Individuals with Chronic Chagas Disease: Describes the use of guanidine hydrochloride in real-time PCR processes to quantify the parasite burden in blood samples from individuals with Chagas disease, demonstrating its utility in enhancing diagnostic assays (Liempi D et al., 2024).
Disclaimer
Toxicity: Harmful (C)
General description
A powerful protein denaturant that is widely used in the purification of proteins, nucleic acids, and mRNA. It is used in a variety of applications, including sequencing, molecular weight determinations, and as a solubilizing agent for electrophoresis.
Absorbance (6.0 M, H2O): <0.2 at 230 nm; <0.03 at 260 nm.
Other Notes
Bastiras, S., and Wallace, J.C. 1992. Biochemistry31, 9304.
Plaza del Pino, I.M., et al. 1992. Biochemistry31, 11196.
Steinman, H., et al. 1974. J. Biol. Chem.249, 7326.
Plaza del Pino, I.M., et al. 1992. Biochemistry31, 11196.
Steinman, H., et al. 1974. J. Biol. Chem.249, 7326.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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