370625
Guanabenz Acetate
A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.
别名:
Guanabenz Acetate, 1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678
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关于此项目
经验公式（希尔记法）:
C8H8Cl2N4 · xC2H4O2
化学文摘社编号:
分子量:
231.08 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
powder
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Clc1c(c(ccc1)Cl)\C=N\N=C(\[N+H3])/N.[O-]C(=O)C
InChI
1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;
InChI key
MCSPBPXATWBACD-GAYQJXMFSA-N
General description
A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Tsaytler, P., et al. 2011. Science332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol.327, 1.
Erb, S., et al. 2000. Neuropsychopharmacology23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol.327, 1.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
警示词
Danger
危险代码
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable