370679
Guanosine 3′,5′-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt
A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM).
别名:
Guanosine 3′,5′-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt, Rp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI
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关于此项目
经验公式（希尔记法）:
C18H14BrN5O6PS · Na
化学文摘社编号:
分子量:
562.27
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.77
SMILES string
[Na+].[P+]1(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]3c4c(nc3Br)C(=O)[n]5c(nc(c5)c6ccccc6)N4)CO1)([S-])[O-]
InChI
1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31?;/m1./s1
InChI key
SVMPQLHYWRTQCX-WKKXCKAJSA-M
assay
≥98% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µM) and the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKG1α & 1β
PKG1α & 1β
Product does not compete with ATP.
Reversible: no
Target Ki: 30 nM against PKG1α & 1β
Other Notes
Wei, J.Y., et al. 1996. Biochemistry35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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