370695
GW1929
PPARγ agonist, crystalline solid
别名:
GW1929, PPAR Agonist V, PPARγ Agonist IV
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关于此项目
经验公式（希尔记法）:
C30H29N3O4
化学文摘社编号:
分子量:
495.57
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Form:
crystalline solid
Storage condition:
OK to freeze, protect from light
产品名称
GW1929, A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays).
Quality Segment
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N([C@@H](Cc3ccc(cc3)OCCN(C)c4ncccc4)C(=O)O)c1c(cccc1)C(=O)c2ccccc2
InChI
1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
InChI key
QTQMRBZOBKYXCG-MHZLTWQESA-N
General description
A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 13 nM for murine PPARγ and 6.2 nM for human PPARγ in cell-based transactivation assays).
Biochem/physiol Actions
Cell permeable: no
EC50 = 13 nM as peroxisome proliferator-activated receptor γ (PPARγ) agonist for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays
Primary Target
Peroxisome proliferator-activated receptor γ (PPARγ) agonist
Peroxisome proliferator-activated receptor γ (PPARγ) agonist
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Han, S., et al. 2004. Clin. Cancer Res.10, 1911.
Willson, T.M., et al. 2000. J. Med. Chem.43, 527.
Brown, K.K., et al. 1999. Diabetes48, 1415.
Willson, T.M., et al. 2000. J. Med. Chem.43, 527.
Brown, K.K., et al. 1999. Diabetes48, 1415.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1