371721
GPR40 Agonist II
The GPR40 Agonist II controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
GPR40 Agonist II, 3-(4-((2,6-Dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid, FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II, FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II, 3-(4-((2,6-Dichloropyridin-4-yl)ethynyl)phenyl)propanoic acid
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关于此项目
经验公式（希尔记法）:
C16H11Cl2NO2
化学文摘社编号:
分子量:
320.17
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
InChI
1S/C16H11Cl2NO2/c17-14-9-13(10-15(18)19-14)6-5-11-1-3-12(4-2-11)7-8-16(20)21/h1-4,9-10H,7-8H2,(H,20,21)
InChI key
GCWBKYDSSJIRNJ-UHFFFAOYSA-N
SMILES string
ClC1=NC(Cl)=CC(C#CC2=CC=C(CCC(O)=O)C=C2)=C1
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 100 mg/mL, clear, colorless
shipped in
wet ice
Quality Level
General description
A cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50 = 40.7 nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12 mM glucose-induced insulin secretion from rat INS-1E β-cells (by 34% at 10 µM) and exhibit good aqueous solubility (199 µM in PBS at pH 7.4), as well as chemical (0.1% degradation after 12 days in PBS at 37 °C) and metabolic (3% metabolization by human liver S9 stability test) stability.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
Other Notes
Christiansen, E., et al. 2011, J. Med. Chem.54, 6691.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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