371724
GPR119 Agonist, AS1269574
The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
GPR119 Agonist, AS1269574, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist
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关于此项目
经验公式（希尔记法）:
C13H14BrN3O
化学文摘社编号:
分子量:
308.17
UNSPSC Code:
51111800
NACRES:
NA.51
MDL number:
InChI
1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17)
SMILES string
BrC(C=C1)=CC=C1C2=NC(C)=CC(NCCO)=N2
InChI key
DUKPGOOUJNUIOI-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
amber
solubility
DMSO: >10 mg/mL
shipped in
ambient
Quality Level
General description
A pyrimidine compound that acts as an effective GPR119 agonist (EC50 = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.22, 0.29, 0.44, respectively, with 0, 1, 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (26% decrease and 60% increase, respectively, of control blood glucose and insulin AUC0-1h in OGTT; 100 mg/kg; p.o.) without affecting basal blood glucose level in either fed or fasting mice in vivo.
Packaging
Packaged under inert gas
Other Notes
Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun.400, 437.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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