371818
G蛋白βγ 结合肽，mSIRK
A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange.
别名:
G蛋白βγ 结合肽，mSIRK
产品名称
G蛋白βγ 结合肽，mSIRK, A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange.
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
主要靶标
N-肉豆蔻酰化G蛋白βγ选择性结合
N-肉豆蔻酰化G蛋白βγ选择性结合
产物不与ATP竞争。
可逆：否
对大鼠动脉平滑肌和Rat2细胞ERK1/2激活的EC50 ~ 2.5 - 5 µM
细胞可渗透性：是
Disclaimer
毒性：标准处理（A）
General description
一种细胞可渗透的N-肉豆蔻酰化G蛋白βγ选择性结合肽，在不刺激核苷酸交换的情况下破坏α和βγ亚基之间的交互效应并促进α亚基解离。显示可引起大鼠动脉平滑肌和Rat2细胞中ERK1/2的快速激活（EC50 ~2.5-5 µM）。还会促进JNK和p38 MAP激酶，磷脂酶C的磷酸化，并导致Ca2+从内部存储中释放出来。也可用阴性对照（目录编号371820）。
Other Notes
Myr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻（-20°C）。储备溶液在 -20°C 下可稳定保存 4 个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Zhi-Wei Zhang et al.
Molecular medicine reports, 21(2), 720-730 (2020-01-25)
In the present study, the mechanism by which carboxyl terminal activating region 3 (CTAR3) of latent membrane protein 1 (LMP1), encoded by the Epstein‑Barr virus, regulated cell proliferation and protein expression was investigated in the nasopharyngeal epithelial cell line NP69.
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