373210
BLT-1
≥95% (HPLC), solid, HDL receptor SR-BI inhibitor, Calbiochem®
别名:
HDL受体SR-BI抑制剂，BLT-1
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关于此项目
经验公式（希尔记法）:
C12H23N3S
化学文摘社编号:
分子量:
241.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
HDL受体SR-BI抑制剂，BLT-1, The HDL Receptor SR-BI Inhibitor, BLT-1, also referenced under CAS 321673-30-7, controls the biological activity of HDL Receptor SR-B. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
InChI
1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+
InChI key
OWGUSBISUVLUJF-SDNWHVSQSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
ambient
Quality Level
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General description
一种细胞可渗透的氨基硫脲铜螯合剂，以可逆的方式有效阻断HDL受体SR-BI-（清道夫受体，B类，I型）介导的脂质摄取（使用表达鼠SR-BI的仓鼠ldlA-7细胞，对于来自DiI-HDL和CE-HDL的DiI和CE摄取，IC50分别为21和57 nM），而对细胞内膜运输或细胞骨架组织几乎没有效应。BLT-1以2:1的化学计量比螯合Cu+2，并且显示半摩尔当量的CuCl2可以完全防止斑马鱼胚胎免受BLT-1诱导的发育缺陷的影响，而BLT-1同样可以用于螯合过量的铜（>4 µM），并从铜毒性中拯救胚胎。
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
Other Notes
Nieland, T.J.F., et al. 2008.Biochemistry47, 460.
Raldua, D., and Babin, P.J.2007.Toxicol.Lett.175, 1.
Nieland, T.J.F., et al. 2002.Proc.Natl.Acad.Sci. USA99, 15422.
Peterson, R.T., et al. 2000.Proc.Natl.Acad.Sci. USA97, 12965.
Raldua, D., and Babin, P.J.2007.Toxicol.Lett.175, 1.
Nieland, T.J.F., et al. 2002.Proc.Natl.Acad.Sci. USA99, 15422.
Peterson, R.T., et al. 2000.Proc.Natl.Acad.Sci. USA97, 12965.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Thomas J F Nieland et al.
Biochemistry, 47(1), 460-472 (2007-12-11)
Scavenger receptor, class B, type I (SR-BI), controls high-density lipoprotein (HDL) metabolism by mediating cellular selective uptake of lipids from HDL without the concomitant degradation of the lipoprotein particle. We previously identified in a high-throughput chemical screen of intact cells
R T Peterson et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(24), 12965-12969 (2000-11-23)
Much has been learned about vertebrate development by random mutagenesis followed by phenotypic screening and by targeted gene disruption followed by phenotypic analysis in model organisms. Because the timing of many developmental events is critical, it would be useful to
Thomas J F Nieland et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(24), 15422-15427 (2002-11-20)
The high-density lipoprotein (HDL) receptor, scavenger receptor, class B, type I (SR-BI), mediates both the selective uptake of lipids, mainly cholesterol esters, from HDL to cells and the efflux of cholesterol from cells to lipoproteins. The mechanism underlying these lipid
Demetrio Raldúa et al.
Toxicology letters, 175(1-3), 1-7 (2007-09-25)
Block lipid transport-1 (BLT-1) is a small chemical widely used to inhibit the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by scavenger receptor B, type 1 (SR-BI). This study demonstrated that BLT-1 induced in zebrafish (Danio rerio)
Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1.
Pang, et al.
Nature Communications, 14, 2656-2656 (2023)
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