Heat Shock Protein Inhibitor I

Name: Heat Shock Protein Inhibitor I
Brand: MM

Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.

别名:

Heat Shock Protein Inhibitor I, KNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₁NO₄

化学文摘社编号:

218924-25-5

分子量:

245.23

MDL number:

MFCD24369049

UNSPSC Code:

12352202

NACRES:

NA.77

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InChI key

LZGGUFLRKIMBDQ-UHFFFAOYSA-N

SMILES string

N1(CCC(=Cc2cc3c(cc2)OCO3)C1=O)C=O

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white to light yellow

solubility

DMSO: 3 mg/mL, olive oil: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.

A benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Hsp70

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.

Other Notes

Koishi, M., et al. 2001. Clin. Cancer Res.7, 215.
Yokota, S., et al. 2000. Cancer Res.60, 2942.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Heat Shock Protein Inhibitor I