Heat Shock Protein Inhibitor I

Name: Heat Shock Protein Inhibitor I
Brand: MM

Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.

别名:

Heat Shock Protein Inhibitor I, KNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₁NO₄

CAS Number:

218924-25-5

分子量:

245.23

MDL编号:

MFCD24369049

UNSPSC代码:

12352202

NACRES:

NA.77

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质量水平

100

方案

≥95% (HPLC)

表单

powder

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

white to light yellow

溶解性

DMSO: 3 mg/mL
olive oil: soluble

运输

ambient

储存温度

−20°C

SMILES字符串

N1(CCC(=Cc2cc3c(cc2)OCO3)C1=O)C=O

InChI key

LZGGUFLRKIMBDQ-UHFFFAOYSA-N

一般描述

A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.

A benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.

生化/生理作用

Cell permeable: no

Primary Target
Hsp70

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

制备说明

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.

其他说明

Koishi, M., et al. 2001. Clin. Cancer Res.7, 215.
Yokota, S., et al. 2000. Cancer Res.60, 2942.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Harmful (C)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Heat Shock Protein Inhibitor I