373273-M
Hh Signaling Antagonist XIV, SANT-2
The Hh Signaling Antagonist XIV, SANT-2, also referenced under CAS 329196-48-7, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.
别名:
Hh Signaling Antagonist XIV, SANT-2, N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-tris(ethyloxy)benzamide, Smo Antagonist V
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关于此项目
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
storage temp.
2-8°C
form
powder
InChI key
VQOJFGFKIVFMDH-UHFFFAOYSA-N
InChI
1S/C26H26ClN3O4/c1-4-32-22-13-16(14-23(33-5-2)24(22)34-6-3)26(31)28-17-11-12-19(27)18(15-17)25-29-20-9-7-8-10-21(20)30-25/h7-15H,4-6H2,1-3H3,(H,28,31)(H,29,30)
assay
≥95% (HPLC)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mg/mL, ethanol: 25 mg/mL
General description
A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303 ), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 µM).
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Rominger, C.M., et al. 2009. J. Pharmacol. Exp. Ther.329, 995.
Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA106, 3196.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.
Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA106, 3196.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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