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373402

Hedgehog Antagonist VIII

Name: Hedgehog Antagonist VIII
Brand: MM

The Hedgehog Antagonist VIII, also referenced under CAS 330796-24-2, controls the biological activity of Hedgehog. This small molecule/inhibitor is primarily used for Cell Signaling applications.

别名:

Hedgehog Antagonist VIII, 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl)methyl)-urea, Hh Signaling Antagonist VIII, Hh Signaling Antagonist VIII, 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl)methyl)-urea

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关于此项目

经验公式（希尔记法）:

C₂₃H₁₅ClF₄N₄O₂

化学文摘社编号:

330796-24-2

分子量:

490.84

MDL number:

MFCD10567691

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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属性

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

clear slightly yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

FC(F)(F)c1c(ccc(c1)NC(=O)NCc2[n]([c](c4c(n2)cccc4)=O)c3ccc(cc3)F)Cl

InChI

1S/C23H15ClF4N4O2/c24-18-10-7-14(11-17(18)23(26,27)28)30-22(34)29-12-20-31-19-4-2-1-3-16(19)21(33)32(20)15-8-5-13(25)6-9-15/h1-11H,12H2,(H2,29,30,34)

InChI key

NYOXUHUPXGFHIB-UHFFFAOYSA-N

说明

General description

A cell-permeable quinazolinyl-urea compound that is shown to potently inhibit OCT-Shh-stimulated Gli transcription activity in a 10t1/2(s12) cell-based Luciferase reporter assay (IC₅₀ = 70 nM).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C0. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Brunton, A.A., et al. 2008. J. Med. Chem.51, 1108.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c