374825
血蓝蛋白，钥孔虫戚，大水母，高纯度，无内毒素，无菌液体
Hemocyanin, Keyhole Limpet, Megathura crenulata, High Purity, Endotoxin Free, is a large, multi-subunit, O2-carrying, metalloprotein that is used as a carrier protein in the production of antibodies.
别名:
血蓝蛋白，钥孔虫戚，大水母，高纯度，无内毒素，无菌液体
产品名称
血蓝蛋白，钥孔虫戚，大水母，高纯度，无内毒素，无菌液体, Hemocyanin, Keyhole Limpet, Megathura crenulata, High Purity, Endotoxin Free, is a large, multi-subunit, O2-carrying, metalloprotein that is used as a carrier protein in the production of antibodies.
assay
≥95% (size exclusion chromatography)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
impurities
≤25 EU/mg Endotoxin
≥1.5 x 10⁻³ copper to protein ratio
≥5 mg/mL Protein
color
clear bluish
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Application
来自大锁孔帽贝的匙孔血蓝蛋白，高纯度，无内毒素，无菌液体，已作为抗原用于通过酶联免疫吸附剂测定（ELISA）测试单克隆抗体（mAb）的多反应性。它也已用于使动物免疫以研究猴子中的KLH特异性体外 回忆反应（recall response）和特异性T细胞依赖性抗体反应（TDAR）。
Biochem/physiol Actions
匙孔血蓝蛋白（KLH）刺激动物和人类中细胞介导的反应和体液反应。它诱发免疫刺激特性并可作为疫苗佐剂。KLH可作为载体蛋白用于生产抗体和半抗原，如肽和寡糖。它也可用于治疗膀胱癌。
Disclaimer
毒性：标准处理（A）
General description
匙孔血蓝蛋白（KLH）是一种大型的多亚基、携氧金属蛋白。这种高分子量糖蛋白是由海洋蜗牛大锁孔帽贝提取而来。
Packaging
请参考特定浓度批号的标签。
Physical form
在83 mM磷酸钠，150 mM NaCl（pH 7.2）中。
Preparation Note
KLH是一种极大的蛋白复合物，具有在溶液中聚集和沉淀的趋势。 稀释KLH时使用缓冲液，并将镁浓度保持在≥10 mM。 KLH 溶液在 4°C下储存。切勿冷冻、涡旋处理或搅拌以溶解KLH。冷冻或搅拌KLH将导致蛋白质聚集和沉淀。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Joshua T Gamse et al.
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The OX40 receptor plays a crucial co-stimulatory role in T effector cell survival, expansion, cytokine production, and cytotoxicity to tumor cells; therefore, OX40 agonists are being evaluated as anti-cancer immunotherapies, especially in combination with checkpoint inhibitors. To support clinical development
Oyindasola Oyelaran et al.
Proteomics. Clinical applications, 4(3), 285-294 (2010-12-08)
Keyhole limpet hemocyanin (KLH) is used as a vaccine adjuvant, as a carrier protein for small haptens, and as a treatment for bladder cancer. Immunization with KLH produces antibodies to tumor-associated carbohydrate antigens (TACAs) in animals, and these antibodies have
Erik H J G Aarntzen et al.
Cancer immunology, immunotherapy : CII, 61(11), 2003-2011 (2012-04-25)
Keyhole limpet hemocyanin (KLH) attracts biomedical interest because of its remarkable immunostimulatory properties. Currently, KLH is used as vaccine adjuvant, carrier protein for haptens and as local treatment for bladder cancer. Since a quantitative human anti-KLH assay is lacking, it
Jenna J Guthmiller et al.
Immunity, 53(6), 1230-1244 (2020-10-24)
Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses.
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