377980
Hispidin
A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC50 = 2 µM).
别名:
Hispidin, 6-(3,4-Dihydroxystyrl)-4-hydroxy-2-pyrone
InChI
1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,15-17H/b3-1+
InChI key
QISBNGLMCHHHFG-HNQUOIGGSA-N
assay
≥90% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
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General description
A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC50 = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKCβ
PKCβ
Product does not compete with ATP.
Reversible: yes
Target IC50: 2 µM against PKCβ
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Gonindard, C., et al. 1997. Cell Biol. Toxicol. 13, 141.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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