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Merck
CN

382110

Histone Acetyltransferase Inhibitor II

The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

别名:

Histone Acetyltransferase Inhibitor II, 2,6- bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I, 2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I

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关于此项目

经验公式（希尔记法）:
C20H16Br2O3
化学文摘社编号:
932749-62-7
分子量:
464.15
MDL编号:
MFCD11655778
UNSPSC代码:
12352200
NACRES:
NA.77

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质量水平

100

方案

≥97% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

yellow

溶解性

ethanol: 10 mg/mL
DMSO: 25 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

Brc1c(ccc(c1)\C=C2/CCC\C(=C/c3cc(c(cc3)O)Br)\C/2=O)O

InChI

1S/C20H16Br2O3/c21-16-10-12(4-6-18(16)23)8-14-2-1-3-15(20(14)25)9-13-5-7-19(24)17(22)11-13/h4-11,23-24H,1-3H2/b14-8+,15-9+

InChI key

YOLKEKNTCBWPSD-VOMDNODZSA-N

相关类别

一般描述

A cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤ 40 µM) and induce chromatin condensation in HeLa cells.

包装

Packaged under inert gas

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.

其他说明

Costi, R., et al. 2007. J. Med. Chem.50, 1973.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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