382172
Histone Deacetylase Inhibitor VI, HNHA
The Histone Deacetylase Inhibitor VI, HNHA, also referenced under CAS 926908-04-5, controls the biological activity of Histone Deacetylase.
别名:
Histone Deacetylase Inhibitor VI, HNHA, N-Hydroxy-7-(2-naphthylthio)heptanomide
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
methanol: 10 mg/mL
DMSO: 100 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
S(CCCCCCC(=O)NO)c1cc2c(cc1)cccc2
InChI
1S/C17H21NO2S/c19-17(18-20)9-3-1-2-6-12-21-16-11-10-14-7-4-5-8-15(14)13-16/h4-5,7-8,10-11,13,20H,1-3,6,9,12H2,(H,18,19)
InChI key
KPNNXHVGOKRBEF-UHFFFAOYSA-N
一般描述
A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Kim, D.H., et al. 2007. Biochem. Biophys. Res. Commun.356, 233.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Dong Hoon Kim et al.
Biochemical and biophysical research communications, 356(1), 233-238 (2007-03-14)
Histone deacetylase (HDAC), a key enzyme in gene expression and carcinogenesis, is considered an attractive target molecule for cancer therapy. Here, we report a new synthetic small molecule, N-hydroxy-7-(2-naphthylthio) heptanomide (HNHA), as a HDAC inhibitor with anti-tumor activity both in
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