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Merck
CN

382180

Histone Deacetylase 6, GST-Fusion, Human Recombinant, S. frugiperda

Histone Deacetylase 6, GST-Fusion, Human Recombinant, S. frugiperda, is a full-length HDAC6 fused to GST at the N-terminus. Useful in the study of HDAC6 regulation and for inhibitor screening.

别名:

HDAC6, Human, Recombinant

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关于此项目

NACRES:
NA.54
UNSPSC Code:
12352202
Specific activity:
≥50 units/μg protein
Assay:
≥80% (SDS-PAGE)
Recombinant:
expressed in insect cells (S. frugiperda)

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recombinant

expressed in insect cells (S. frugiperda)

assay

≥80% (SDS-PAGE)

form

liquid

specific activity

≥50 units/μg protein

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

General description

Full length, recombinant, human histone deacetylase 6 (HDAC6) fused to GST at the N-terminus and expressed in S. frugiperda insect cells using a baculovirus expression system. Actively maintained in the cytoplasm, HDAC6 is uniquely dependent on its ubiquitin-binding domain and functions at the nexus between two cellular signaling systems, involving protein acetylation and ubiquitination. The active deacetylase is useful in the study of HDAC6 regulation and for inhibitor screening.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

40 mM Tris-HCl pH8.0, 110mM NaCl, 2.2 mM KCl, 0.04% Tween 20, 3mM DTT, and 20% glycerol.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

One unit is defined as the amount of enyme that is required to deacetylate 1 pmol fluorescent HDAC peptide substrate per min at 30°C.
Pandey, U.B., et al. 2007. Nature447, 859.
Hubbert, C., et al. 2002. Nature417, 455.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

10 - Combustible liquids

wgk

WGK 1

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Jin Kyun Park et al.
Arthritis research & therapy, 23(1), 177-177 (2021-07-07)
To investigate the effects of inhibiting histone deacetylase (HDAC) 6 on inflammatory responses and tissue-destructive functions of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). FLS from RA patients were activated with interleukin (IL)-1β in the presence of increasing concentrations of
Nina Ha et al.
British journal of pharmacology, 177(22), 5096-5113 (2021-01-19)
Charcot-Marie-Tooth (CMT) disease is the most common hereditary peripheral neuropathy. CMT type 1A (CMT1A) accounts for approximately 50% of CMT patients and is linked to PMP22 gene duplication. Histone deacetylase-6 (HDAC6) has pleiotropic effects, such as regulating lipid homeostasis and

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