382425
Trequinsin, Hydrochloride
Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro.
别名:
Trequinsin, Hydrochloride, 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C24H27N3O3 · xHCl
化学文摘社编号:
分子量:
405.49 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
描述
RTECS - UW7727000
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
颜色
pale yellow
溶解性
water: 500 μM
运输
ambient
储存温度
10-30°C
SMILES字符串
Cl.[n]21c(c[c]([n]([c]2=O)C)=Nc4c(cc(cc4C)C)C)c3c(cc(c(c3)OC)OC)CC1
InChI
1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H
InChI key
DTCZZBVPTHVXFA-UHFFFAOYSA-N
一般描述
Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
生化/生理作用
Cell permeable: yes
Primary Target
cGMP-inhibited phosphodiesterase
cGMP-inhibited phosphodiesterase
Product does not compete with ATP.
Reversible: no
Target IC50: 300 pM against cGMP-inhibited phosphodiesterase
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Spina, D., et al. 1998. Life Sci. 62, 953.
Pillai, R., et al. 1994. J. Biol. Chem.269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol.268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci.31, 2037.
Pillai, R., et al. 1994. J. Biol. Chem.269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol.268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci.31, 2037.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持