384620
Honokiol
A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.
别名:
Honokiol, 5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H18O2
化学文摘社编号:
分子量:
266.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Honokiol, A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.
SMILES string
Oc1c(cc(cc1)c2c(ccc(c2)CC=C)O)CC=C
InChI
1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
InChI key
FVYXIJYOAGAUQK-UHFFFAOYSA-N
description
Merck USA index - 14, 4742
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 10 mg/mL
ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
Anti-angiogenic, anti-tumor and anxiolytic properties
Anti-angiogenic, anti-tumor and anxiolytic properties
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.
The active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice.
Other Notes
Bai, X., et al. 2003. J. Biol. Chem.278, 35501.
Yang, S.E., et al. 2002. Biochem. Pharmacol.63, 1641.
Son, H.J., et al. 2000. Planta Med.66, 469.
Maruyama, Y., et al. 1998. J. Nat. Prod.61, 135.
Yang, S.E., et al. 2002. Biochem. Pharmacol.63, 1641.
Son, H.J., et al. 2000. Planta Med.66, 469.
Maruyama, Y., et al. 1998. J. Nat. Prod.61, 135.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持