385920
HSP90 Inhibitor, CCT018159
The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.
别名:
HSP90 Inhibitor, CCT018159, 4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
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关于此项目
经验公式（希尔记法）:
C20H20N2O4
化学文摘社编号:
分子量:
352.38
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[nH]1nc(c(c1C)c3cc4c(cc3)OCCO4)c2c(cc(c(c2)CC)O)O
InChI
1S/C20H20N2O4/c1-3-12-8-14(16(24)10-15(12)23)20-19(11(2)21-22-20)13-4-5-17-18(9-13)26-7-6-25-17/h4-5,8-10,23-24H,3,6-7H2,1-2H3,(H,21,22)
InChI key
OWPMENVYXDJDOW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 1.7 mg/mL, DMSO: 35 mg/mL, ethanol: 35 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC50 = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme′s N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.
Other Notes
Hardcastle, A., et al. 2007. Mol. Cancer Ther.6, 1112.
Sharp, S.Y., et al. 2007. Cancer Res.67, 2206.
Smith, N.F., et al. 2006. Mol. Cancer Ther.5, 1628.
Dymock, B.W., et al. 2005. J. Med. Chem.48, 4212.
Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett.15, 3338.
Sharp, S.Y., et al. 2007. Cancer Res.67, 2206.
Smith, N.F., et al. 2006. Mol. Cancer Ther.5, 1628.
Dymock, B.W., et al. 2005. J. Med. Chem.48, 4212.
Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett.15, 3338.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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