390238
Camptothecin
from Camptotheca acuminata, ≥95% (HPLC), powder, DNA topoisomerase I inhibitor, Calbiochem®
别名:
Camptothecin, 10-Hydroxy-, Camptotheca acuminata, 10-Hydroxycamptothecin, HCPT
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关于此项目
经验公式（希尔记法）:
C20H16N2O5
化学文摘社编号:
分子量:
364.35
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
OK to freeze
产品名称
Camptothecin, 10-Hydroxy-, Camptotheca acuminata, A cell-permeable powerful DNA topoisomerase I inhibitor.
Quality Segment
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
pale yellow
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[n]21c(cc5c([c]2=O)COC(=O)C5(O)CC)c3nc4c(cc3C1)cc(cc4)O
InChI
1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
InChI key
HAWSQZCWOQZXHI-UHFFFAOYSA-N
General description
A cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
A cell-permeable, powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Inhibits the proliferation of hepatoma HepG2, Bcl-7402 and Bcl-7404 cells in a dose-dependent manner. Has selective inhibitory effect on the phosphorylation of histones H1 and H3, but is less effective on other histones.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
DNA topoisomerase I
DNA topoisomerase I
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Zhang, X.W., et al. 1999. Anticancer Drugs.10, 569.
Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
Wani, M.C., and Wall, M.E. 1969. J. Org.Chem.34, 1364.
Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
Wani, M.C., and Wall, M.E. 1969. J. Org.Chem.34, 1364.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Muta. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable