397100
HNMPA-(AM)3
A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases.
别名:
HNMPA-(AM)3, Hydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II
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关于此项目
经验公式（希尔记法）:
C20H23O10P
化学文摘社编号:
分子量:
454.36
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
HNMPA-(AM)3, A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases.
InChI key
UQODAZKXEREJLZ-UHFFFAOYSA-N
InChI
1S/C20H23O10P/c1-14(21)25-11-28-20(19-9-8-17-6-4-5-7-18(17)10-19)31(24,29-12-26-15(2)22)30-13-27-16(3)23/h4-10,20H,11-13H2,1-3H3
SMILES string
[P](=O)(OCOC(=O)C)(OCOC(=O)C)C(OCOC(=O)C)c1cc2c(cc1)cccc2
assay
≥98% (TLC)
form
oil
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
colorless
solubility
DMSO: 20 mg/mL
ethanol: 20 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Biochem/physiol Actions
Cell permeable: yes
Primary Target
tyrosine kinase
tyrosine kinase
Product does not compete with ATP.
Reversible: no
Target IC50: 100 µM and 10 µM against insulin receptor tyrosine kinase and insulin-stimulated glucose oxidation in isolated rat adipocytes, respectively
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases. Inhibits insulin receptor tyrosine kinase (IC50 = 100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µM).
A cell-permeable analog of HNMPA. Inhibits insulin receptor tyrosine kinase (IC50 = 100 mM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µM). It has no effect on PKA (at concentrations up to 1 mM) or PKC (at concentrations up to 420 µM).
Other Notes
Baltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA89, 7885.
Saperstein, R., et al. 1989. Biochemistry28, 5694.
Saperstein, R., et al. 1989. Biochemistry28, 5694.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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