400011
Caspase-1抑制剂I，细胞可渗透
The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Caspase-1抑制剂I，细胞可渗透
assay
≥97% (HPLC)
form
solid
potency
1 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
General description
半胱天冬酶-1（ICE；白介素-1β转化酶）、半胱天冬酶-4和半胱天冬酶-5的细胞渗透性抑制剂。该肽的C端YVAD-CHO序列是半胱天冬酶-1（Ki=1 nM）的高度特异性，有效和可逆抑制剂。N-末端序列（氨基酸残基1-16）对应于Kaposi成纤维细胞生长因子（K-FGF）的信号肽的疏水区（H-区），并赋予该肽细胞渗透性。
Biochem/physiol Actions
主要靶标
半胱天冬酶-1
半胱天冬酶-1
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
Preparation Note
复溶后，等分并冷冻（-20°C）。储备液可在-20°C最长稳定1个月。
Other Notes
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
Garcia-Calvo, M., et al. 1998.J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998.J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998.Science 281, 1312.
Lin, Y.-Z., et al. 1996.J. Biol. Chem.271, 5305.
Lin, Y.-Z., et al. 1995.J. Biol. Chem.270, 14255.
Reiter, L.A.1994.Int. J. Pept. Protein Res.43, 87.
Thornberry, N.A., et al. 1994.Biochemistry33, 3934.
Thornberry, N.A., et al. 1994.MethodsEnzymol.244, 615.
Thornberry, N.A., et al. 1992.Nature 356, 768.
Hilbi, H., et al. 1998.J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998.Science 281, 1312.
Lin, Y.-Z., et al. 1996.J. Biol. Chem.271, 5305.
Lin, Y.-Z., et al. 1995.J. Biol. Chem.270, 14255.
Reiter, L.A.1994.Int. J. Pept. Protein Res.43, 87.
Thornberry, N.A., et al. 1994.Biochemistry33, 3934.
Thornberry, N.A., et al. 1994.MethodsEnzymol.244, 615.
Thornberry, N.A., et al. 1992.Nature 356, 768.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
C C Teixeira et al.
American journal of physiology. Cell physiology, 281(3), C833-C839 (2001-08-15)
An elevation in inorganic phosphate (P(i)) concentration activates epiphyseal chondrocyte apoptosis. To determine the mechanism of apoptosis, tibial chondrocytes were treated with P(i), and nitrate/nitrite (NO/NO) levels were determined. P(i) induced a threefold increase in the NO/NO concentration; inhibitors of
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