InChI key
BJRPPNOJYFZSLY-UHFFFAOYSA-N
InChI
1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29)
SMILES string
N(c5c(ccc(c5)C(=O)OC)O)C(=O)COc1ccc(cc1)C32CC4CC(C3)CC(C2)C4
form
(Light beige powder)
storage condition
OK to freeze
solubility
soluble (DMSO (10 mg/ml))
storage temp.
2-8°C
Quality Level
General description
A cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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