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401477

IκB Kinase Inhibitor Peptide, Cell-Permeable

Name: IκB Kinase Inhibitor Peptide, Cell-Permeable
Brand: MM

The IκB Kinase Inhibitor Peptide, Cell-Permeable controls the biological activity of IκB Kinase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

别名:

IκB Kinase Inhibitor Peptide, Cell-Permeable, Ac- AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂, Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂

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关于此项目

经验公式（希尔记法）:

C₁₃₈H₂₂₉N₃₇O₄₅S

分子量:

3158.58

NACRES:

NA.77

UNSPSC Code:

12352202

Assay:

≥95% (HPLC)

Form:

lyophilized

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Quality Level

100

assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

solubility

PBS, pH 7.4: 1 mg/mL

shipped in

wet ice

storage temp.

−20°C

General description

A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (<50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.

Biochem/physiol Actions

Cell permeable: no

Primary Target
LPS-induced IκB degradation by IKK in RAW 264.7 cells

Product does not compete with ATP.

Reversible: no

Target IC₅₀: <50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂

Swaroop, N., et al. 2001. Pharm. Res.18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J.14, 2876.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c