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About This Item
经验公式（希尔记法）:
C16H11N3O5S
CAS Number:
分子量:
357.34
MDL编号:
UNSPSC代码:
12352106
NACRES:
NA.77
质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
dark red
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
[S](=O)(=O)(O)c1c[c]2[c](cc1)=NC(=O)C=2c3[nH]c4c(c3NO)cccc4
InChI
1S/C16H11N3O5S/c20-16-13(10-7-8(25(22,23)24)5-6-12(10)18-16)15-14(19-21)9-3-1-2-4-11(9)17-15/h1-7,17,19,21H,(H,22,23,24)
InChI key
IZDNACYDKBNHHC-UHFFFAOYSA-N
一般描述
A highly potent, reversible, and selective inhibitor of cyclin-dependent kinases 1 and 5 (IC50 = 5 nM for CDK1; IC50 = 7 nM for CDK5). Reported to act by competing with ATP for binding to the catalytic site of the kinase. Also acts as a potent inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM).
A potent, reversible, and selective inhibitor of Cdk1 (IC50 = 5 nM) and Cdk5 (IC50 = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM). The inhibition is competitive with respect to ATP.
生化/生理作用
Cell permeable: no
Primary Target
CDK1
CDK1
Product competes with ATP.
Reversible: yes
Target IC50: 5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
其他说明
Leclerc, S., et al. 2001. J. Biol. Chem.276, 251.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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