405210
ID-8
A cell-permeable indole compound that, when added to murine D3ES ESC (embryonic stem cell) cultures in the absence of serum and MEF (murine embryonic fibroblast) feeder cells, serves as a cheaper, chemical alternative to LIF
别名:
ID-8, 1-(4-Methoxyphenyl)-2-methyl-3-nitro-indol-6-ol
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关于此项目
经验公式（希尔记法）:
C16H14N2O4
化学文摘社编号:
分子量:
298.29
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.51
InChI key
VVZNWYXIOADGSW-UHFFFAOYSA-N
InChI
1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3
SMILES string
[N+](=O)([O-])c1c2c([n](c1C)c3ccc(cc3)OC)cc(cc2)O
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
Quality Level
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General description
A cell-permeable indole compound that, when added (10 µM) to murine D3ES ESC (embryonic stem cell) cultures in the absence of serum and MEF (murine embryonic fibroblast) feeder cells, serves as a cheaper, chemical alternative to LIF (1,000 units/ml) for expanding ESCs in their undifferentiated state. Long-term murine ESCs maintained under ID-8 are capable of differentiating and EBs (Embryoid Bodies) formation upon ID-8 removal. Also claimed to maintain human ESCs in their pluripotent state in the absence of MEF.
Packaging
Packaged under inert gas
Other Notes
Miyabayashi, T., et al. 2008. Biosci. Biotechnol. Biochem.72, 1242.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
Tomoyuki Miyabayashi et al.
Bioscience, biotechnology, and biochemistry, 72(5), 1242-1248 (2008-05-08)
Embryonic stem cells (ESCs), which have characteristics such as self-renewal, indefinite proliferation, and pluripotency, are thought to hold great promise for regenerative medicine. ESCs are generally cultured on mouse embryonic fibroblast (MEF) or MEF conditioned medium (MEF-CM). However, for therapeutic
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