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405210

ID-8

Name: ID-8
Brand: MM

A cell-permeable indole compound that, when added to murine D3ES ESC (embryonic stem cell) cultures in the absence of serum and MEF (murine embryonic fibroblast) feeder cells, serves as a cheaper, chemical alternative to LIF

别名:

ID-8, 1-(4-Methoxyphenyl)-2-methyl-3-nitro-indol-6-ol

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₄N₂O₄

化学文摘社编号:

147591-46-6

分子量:

298.29

MDL number:

MFCD00593367

UNSPSC Code:

12352200

NACRES:

NA.51

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

Quality Level

100

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[N+](=O)([O-])c1c2c([n](c1C)c3ccc(cc3)OC)cc(cc2)O

InChI

1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3

InChI key

VVZNWYXIOADGSW-UHFFFAOYSA-N

说明

General description

A cell-permeable indole compound that, when added (10 µM) to murine D3ES ESC (embryonic stem cell) cultures in the absence of serum and MEF (murine embryonic fibroblast) feeder cells, serves as a cheaper, chemical alternative to LIF (1,000 units/ml) for expanding ESCs in their undifferentiated state. Long-term murine ESCs maintained under ID-8 are capable of differentiating and EBs (Embryoid Bodies) formation upon ID-8 removal. Also claimed to maintain human ESCs in their pluripotent state in the absence of MEF.

Packaging

Packaged under inert gas

Other Notes

Miyabayashi, T., et al. 2008. Biosci. Biotechnol. Biochem.72, 1242.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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存储类别

11 - Combustible Solids

wgk

WGK 3

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Indole derivatives sustain embryonic stem cell self-renewal in long-term culture.

Tomoyuki Miyabayashi et al.

Bioscience, biotechnology, and biochemistry, 72(5), 1242-1248 (2008-05-08)

Embryonic stem cells (ESCs), which have characteristics such as self-renewal, indefinite proliferation, and pluripotency, are thought to hold great promise for regenerative medicine. ESCs are generally cultured on mouse embryonic fibroblast (MEF) or MEF conditioned medium (MEF-CM). However, for therapeutic

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货号	GTIN
405210-10MG	04055977211856