产品名称
Inosine, A metabolite of adenosine that acts as a potent coronary vasodilator. Exhibits a positive inotropic action on heart muscle and can antagonize the ouabain-induced arrhythmias.
SMILES string
[n]2(c3nc[nH][c](c3nc2)=O)C1OC(C(C1O)O)CO
InChI
1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)
InChI key
UGQMRVRMYYASKQ-UHFFFAOYSA-N
description
RTECS - NM7460000
Merck USA index - 14, 4975
assay
≥99% (by assay)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: soluble
shipped in
ambient
storage temp.
15-25°C
Quality Level
General description
A metabolite of adenosine that acts as a potent coronary vasodilator. Exhibits a positive inotropic action on heart muscle and can antagonize the ouabain-induced arrhythmias.
Correlates well with myocardial contractile performance.
Other Notes
Aviado, D.M. 1983. J. Pharmacol. 14 (suppl. 3), 47.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Kyoung-Mi Park et al.
American journal of physiology. Heart and circulatory physiology, 311(2), H371-H383 (2016-06-12)
The nonselective β-adrenergic receptor antagonist (β-blocker) carvedilol has been shown to protect against myocardial injury, but the detailed underlying mechanisms are unclear. We recently reported that carvedilol stimulates the processing of microRNA (miR)-199a-3p and miR-214 in the heart via β-arrestin1-biased
Hsiao-Chun Chen et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 49(5), 1813-1824 (2018-09-20)
Acupuncture involves inserting a fine needle into a specific point, often called an acupoint, thereby initiating a therapeutic effect accompanied by phenomena such as soreness, heaviness, fullness, and numbness. Acupoints are characterized as points located in deep tissues with abundant
Srinivasa Rao Bolla et al.
Heliyon, 5(5), e01648-e01648 (2019-06-14)
Identification and assessment of therapeutic potential of natural products derived from medicinal plants have led to the discovery of innovative and economical drugs to treat several diseases, including chronic wounds. In vitro cell based scratch assay is an appropriate and
Juan M Roldan-Romero et al.
International journal of cancer, 146(5), 1435-1444 (2019-07-25)
The mammalian target of rapamycin (mTOR) pathway inhibitors are key drugs for the treatment of many tumor types, however, there are no predictive biomarkers in clinical use. Here, we performed a molecular and immunohistochemical characterization of key mTOR pathway components
Kunihiko Hinohara et al.
Cancer cell, 34(6), 939-953 (2018-11-26)
Members of the KDM5 histone H3 lysine 4 demethylase family are associated with therapeutic resistance, including endocrine resistance in breast cancer, but the underlying mechanism is poorly defined. Here we show that genetic deletion of KDM5A/B or inhibition of KDM5 activity
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持