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Merck
CN

407125

D-myo-Inositol 1,2,3,4,5,6-Hexakisphosphate, Dodecasodium Salt

≥85% (HPLC), di- and trivalent cation chelator, solid

别名:

D-myo-Inositol 1,2,3,4,5,6-六磷酸十二钠盐，来源于玉米须

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关于此项目

经验公式（希尔记法）:
C6H6O24P6 · 12Na
化学文摘社编号:
17211-15-3
分子量:
923.82
MDL number:
MFCD00065350
UNSPSC Code:
12352211
NACRES:
NA.77

主要文件

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产品名称

D-myo-Inositol 1,2,3,4,5,6-六磷酸十二钠盐，来源于玉米须, Major phosphorus compound in plants that chelates with a variety of di- and trivalent cations.

SMILES string

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[P](=O)([O-])([O-])OC1C(C(C(C(C1O[P](=O)([O-])[O-])O[P](=O)([O-])[O-])O[P](=O)([O-])[O-])O[P](=O)([O-])[O-])O[P](=O)([O-])[O-]

InChI

1S/C6H18O24P6.12Na/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;;;;;;;/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24);;;;;;;;;;;;/q;12*+1/p-12

InChI key

KETSPIPODMGOEJ-UHFFFAOYSA-B

assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white to off-white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

主要靶标
具有多种二价和三价阳离子的螯合物
产物不与ATP竞争。
可逆：否
细胞渗透性：否

Disclaimer

毒性：标准处理（A）

General description

植物中与多种二价和三价阳离子螯合的主要磷化合物。据报道，可抑制破坏性铁催化的氧化还原反应。
植物中的主要磷化合物。具有多种二价和三价阳离子的螯合物。抑制PC-3人前列腺癌细胞的生长并诱导其分化。还报道了抑制破坏性的铁催化的氧化还原反应。

Other Notes

Shamsuddin, A.M., and Yang, G.Y.1995.Carcinogenesis 16, 1975.
Graf, E., and Eaton, J.W.1993.Nutr.Cancer19, 11.

Preparation Note

在复溶后分装并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Hayley Whitfield et al.
The Biochemical journal, 477(14), 2621-2638 (2020-07-25)
Inositol polyphosphates are ubiquitous molecular signals in metazoans, as are their pyrophosphorylated derivatives that bear a so-called 'high-energy' phosphoanhydride bond. A structural rationale is provided for the ability of Arabidopsis inositol tris/tetrakisphosphate kinase 1 to discriminate between symmetric and enantiomeric
Jone Paesmans et al.
eLife, 9 (2020-12-23)
Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer's disease, Down syndrome, and TBC1D24-associated epilepsy, while also loss-of-function mutations in Synj1 are associated with
Yann Desfougères et al.
Methods in molecular biology (Clifton, N.J.), 2091, 59-71 (2019-11-28)
The yeast Saccharomyces cerevisiae has given us much information on the metabolism and function of inositol polyphosphates and inorganic polyphosphate. To expand our knowledge of the metabolic as well as functional connections between inositol polyphosphates and inorganic polyphosphate, we have

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