407325
干扰素-α-IFNα-R互作抑制剂
The Interferon-α-IFNα-R Interaction Inhibitor controls the biological activity of Interferon-α-IFNα-R.
别名:
干扰素-α-IFNα-R互作抑制剂, N-甲基-1-（2-（萘-1-基硫基）苯基）甲胺，HCl，N-甲基-N-（2-（1-萘基硫基）苄基）胺，HCl，IFN-α抑制剂
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关于此项目
经验公式（希尔记法）:
C18H17NS · xHCl
分子量:
279.40 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.32
SMILES string
CNCC1=CC=CC=C1SC2=CC=CC3=C2C=CC=C3.[xHCl]
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
DMSO: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
General description
一种非肽硫代苯基甲胺化合物，在MVA（牛痘病毒Ankara）感染（9 µM的IC50<4.5 µM), TLR9 ligand CpG2216 stimulation, VSV-M2 (vesicular stomatitis virus variant 2) infection, or MDA5/TLR3 ligand poly(I:C) stimulation (by >95%抑制）作用下结合干扰素-α（人IFN-α的Kd = 4 µM）并阻止鼠BM-pDC（骨髓源性浆细胞样树突状细胞）培养物中IFN-α和IFNAR相互作用依赖性IFN-α的产生，同时当以无毒浓度（≤4.5 µM）应用时，对相同培养物中IL-12的产生没有抑制性效应。
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
Other Notes
Geppert, T., et al. 2011.Angew.Chem. Int. Ed.51, 258.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Debasis Nayak et al.
iScience, 25(5), 104193-104193 (2022-04-29)
The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion/cation transporter
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