407621
IL-2Rα Antagonist
The IL-2Rα Antagonist, also referenced under CAS 1217448-66-2, controls the biological activity of IL-2Rα.
别名:
IL-2Rα Antagonist, (R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550
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关于此项目
经验公式（希尔记法）:
C26H30N4O3 · xC2HF3O2
化学文摘社编号:
分子量:
446.54 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
ethanol: 2 mg/mL, DMSO: 28 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
FC(F)(F)C(=O)O.N1(C[C@H](CCC1)CC(=O)N[C@@H](Cc2ccc(cc2)C#Cc3ccccc3)C(=O)OC)\C(=N\[H])\N
InChI
1S/C26H30N4O3.C2HF3O2/c1-33-25(32)23(29-24(31)17-22-8-5-15-30(18-22)26(27)28)16-21-13-11-20(12-14-21)10-9-19-6-3-2-4-7-19;3-2(4,5)1(6)7/h2-4,6-7,11-14,22-23H,5,8,15-18H2,1H3,(H3,27,28)(H,29,31);(H,6,7)/t22-,23+;/m1./s1
InChI key
BVMWPONRCOSTMK-RFPXDPOKSA-N
General description
A non-peptidyl acylphenylalanine compound that binds to IL-2 and acts as a competitive inhibitor of the IL-2/IL-2Rα interaction (IC50 = 3 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibitor of the IL-2/IL-2Rα interaction
Inhibitor of the IL-2/IL-2Rα interaction
Product does not compete with ATP.
Reversible: no
Target IC50: 3 µM against IL-2/IL-2Rα interaction
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Emerson, S.D., et al. 2003. Protein Science12, 811.
Tilley, J.W., et al. 1997. J. Am. Chem. Soc.119, 7589.
Tilley, J.W., et al. 1997. J. Am. Chem. Soc.119, 7589.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable