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Merck
CN
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方案

≥99% (HPLC)

表单

solid

颜色

colorless to white

溶解性

H2O: 20 mg/mL

一般描述

A cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties. Reported to competitively inhibit arginine-dependent mono-ADP-ribosylation, impair mitochondrial respiration, stimulate glycolysis, and prevent terminal differentiation of skeletal myoblasts reversibly. Readily taken up by tissues rich in sympathetic neurons and neuroendocrine neoplasm via norepinephrine transporters (NET). Inhibits the phosphorylation of the Rho effector, PRK1/2 with no effect on the stimulation of MAP and PI-3 kinases.

生化/生理作用

Arginine-dependent mono-ADP-ribosylation

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

储存分类代码

10-13 - German Storage Class 10 to 13


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