407950
Ionomycin free acid
from Streptomyces conglobatus, ≥90% (HPLC), waxy solid, Ca2+ mobile ion carrier, Calbiochem®
别名:
离子霉素，游离酸，Streptomyces conglobatus
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关于此项目
经验公式（希尔记法）:
C41H72O9
化学文摘社编号:
分子量:
709.00
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
产品名称
离子霉素，游离酸，Streptomyces conglobatus, Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+.
InChI
1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33?,36+,37?,39-,40+,41+/m1/s1
InChI key
PGHMRUGBZOYCAA-OJFQOPKISA-N
description
RTECS - NO0600000
assay
≥90% (HPLC)
form
waxy solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
solubility
DMSO: 10 mg/mL, methanol: 10 mg/mL
shipped in
ambient
Quality Level
storage temp.
−20°C
相关类别
General description
对二价阳离子具有高度特异性（Ca2+ > Mg2+ >> Sr2+ = Ba2+）。比抗生素A23187作为Ca2+的移动离子载体更有效。在pH 7和9.5之间与Ca2+的络合，在紫外线范围内产生了显著的吸光值；然而，相比于A23817（货号100105），它是非荧光的。可用于研究Ca2+跨生物膜的运输以及细胞质游离Ca2+的测量。在胚胎皮质神经元中诱导凋亡神经元退化。还可在成熟的伯基特淋巴瘤细胞系的G1间隔期诱导细胞周期阻滞。
对二价阳离子具有高度特异性，并且是比 A23187（货号 100105）更有效的 Ca2+ 移动离子载体。在 pH 7 至 9.5 之间与 Ca2+ 形成复合物。与A23187相比，它没有荧光。可用于研究Ca2+跨生物膜的运输以及细胞质游离Ca2+的测量。诱导胚胎皮质神经元的凋亡神经元变性，并诱导成熟的伯基特淋巴瘤细胞系中 G1 期的细胞周期停滞。
最大吸收 （280 nm，MeOH）：18,600 M-1cm-1。
Biochem/physiol Actions
产物不与ATP竞争。
可逆：否
细胞渗透性：否
首要靶标
Ca2+的移动离子载体
Ca2+的移动离子载体
Packaging
用惰性气体包装
Preparation Note
在重悬后存放于冰箱（4°C）。储备液可在4°C最长稳定1年。
Other Notes
Aagaard-Tillery, K.M., and Jelinek, D.F.1995.J. Immunol.155, 3297.
Takei, N., and Endo, Y. 1994.Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993.J. Cell Physiol.154, 44.
Lee, H.C.1993.J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992.J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979.J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E.1978.J. Biol. Chem.253, 5892.
Takei, N., and Endo, Y. 1994.Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993.J. Cell Physiol.154, 44.
Lee, H.C.1993.J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992.J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979.J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E.1978.J. Biol. Chem.253, 5892.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害（C）
存储类别
10 - Combustible liquids
法规信息
涉药品监管产品
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