410957
3-异丁基-1-甲基黄嘌呤
≥98% (HPLC), solid, cAMP and cGMP phosphodiesterase inhibitor, Calbiochem®
别名:
3-异丁基-1-甲基黄嘌呤
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关于此项目
经验公式（希尔记法）:
C10H14N4O2
化学文摘社编号:
分子量:
222.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
3-异丁基-1-甲基黄嘌呤, A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).
SMILES string
[n]1(c2nc[nH]c2[c]([n]([c]1=O)C)=O)CC(C)C
InChI
1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChI key
APIXJSLKIYYUKG-UHFFFAOYSA-N
description
RTECS - ZD8500000
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
ethanol: 10 mg/mL
DMSO: 100 mM
methanol: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主要靶标
cAMP和cGMP磷酸二酯酶
cAMP和cGMP磷酸二酯酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：2-50 µM，靶向cAMP和cGMP磷酸二酯酶
Disclaimer
毒性：标准处理（A）
General description
cAMP和cGMP磷酸二酯酶的一种非特异性细胞可渗透抑制剂（IC50 = 2-50 µM）。还可作为一种腺苷受体拮抗剂。已报道可抑制TNFα在脂肪细胞前体细胞中的表达。
cAMP和cGMP磷酸二酯酶的细胞可渗透非特异性抑制剂（IC50 = 2-50 µM）。还可作为一种腺苷受体拮抗剂。已报道可抑制TNF-α在脂肪细胞前体细胞中的表达。
Other Notes
Hube, F., et al. 1999.Horm.代谢Res.31, 359.
Morgan, A.J., et al. 1993.生物化学。Pharmacol.45, 2373.
Scamps, F., et al. 1993.Eur. J. Pharmacol.244, 119.
Turner, N.C., et al. 1993.Br. J. Pharmacol.108, 876.
Tamura, T., et al. 1991.J. Gen.Physiol.98, 95.
Beavo, J.A., and Reifsnyder, D.H.1990.Trends Pharmacol.Sci.11, 150.
Russell, T.R.1979.Proc.Natl.Acad.Sci. USA76, 4451.
Morgan, A.J., et al. 1993.生物化学。Pharmacol.45, 2373.
Scamps, F., et al. 1993.Eur. J. Pharmacol.244, 119.
Turner, N.C., et al. 1993.Br. J. Pharmacol.108, 876.
Tamura, T., et al. 1991.J. Gen.Physiol.98, 95.
Beavo, J.A., and Reifsnyder, D.H.1990.Trends Pharmacol.Sci.11, 150.
Russell, T.R.1979.Proc.Natl.Acad.Sci. USA76, 4451.
Preparation Note
可能需要加热才能完全溶解。
在乙醇或甲醇中重溶后，冷藏保存（4°C）。在DMSO中重溶后，等分并冷冻保存（-20°C）。乙醇/甲醇和DMSO储备溶液可分别在4°C或-20°C下稳定保存长达6个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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