412510
IRE1抑制剂I，STF-083010
The IRE1 Inhibitor I, STF-083010 controls the biological activity of IRE1. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
IRE1抑制剂I，STF-083010, N-[（2-羟基萘-1-基）亚甲基]噻吩-2-磺酰胺，N-[（2-羟基-1-萘基）亚甲基]-2-噻吩磺酰胺，ER-核信号1抑制剂I，ERN1抑制剂I，肌醇调节蛋白1抑制剂I，STF083010
SMILES string
[S](=O)(=O)(\N=C\c2c3c(ccc2O)cccc3)c1[s]ccc1
InChI
1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChI key
TVIVJHZHPKNDAQ-MHWRWJLKSA-N
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL, clear, yellow
shipped in
ambient
Quality Level
General description
一种细胞可渗透的水杨基化合物，可直接靶向Ireα1并破坏Ire1-XBP1（X-box结合蛋白），从而在RPMI8226多发性骨髓瘤（MM）细胞中未折叠蛋白反应（UPR）途径。选择性抑制Ire1的ER应激引发的核酸内切酶活性，并在转基因XBP1-luc小鼠（硼替佐米1mg/kg和60 mg/kg STF-083010，i.p.）中以60 µM和XBP1活性阻断MM细胞中XPB1 mRNA的剪接。与B、T和NK细胞相比，对CD138+细胞表现出优先的细胞毒性和抗肿瘤特性。
Packaging
用惰性气体包装
Preparation Note
溶液中不稳定；仅在使用前进行复溶。
Other Notes
Lerner, A.G., et al. 2012 Cell Metabolism16, 250.
Papandreou, I., et al. 2010.Blood117, )1311.
Papandreou, I., et al. 2010.Blood117, )1311.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：监管审查（Z）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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eLife, 11 (2022-05-11)
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous
Jessica Proulx et al.
Frontiers in neuroscience, 16, 906651-906651 (2022-07-06)
Astrocytes are one of the most numerous glial cells in the central nervous system (CNS) and provide essential support to neurons to ensure CNS health and function. During a neuropathological challenge, such as during human immunodeficiency virus (HIV)-1 infection or
Jessica D Rosarda et al.
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The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However, the molecular mechanisms by which 1-dSLs induce toxicity in retinal cells remain poorly understood. Here, we integrate
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