420101
JAK3 抑制剂 I
The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
JAK3 抑制剂 I, 4-（4ʹ-羟基苯基）氨基-6，7-二甲氧基喹唑啉，WHI-P131
选择尺寸
关于此项目
SMILES string
N(c3ccc(cc3)O)c1ncnc2c1cc(c(c2)OC)OC
InChI
1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
InChI key
HOZUXBLMYUPGPZ-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
Biochem/physiol Actions
Janus家族激酶3
Packaging
Other Notes
Sudbeck, E.A., et al. 1999.Clin. Cancer Res.5, 1569.
Goodman, P.A., et al. 1998.J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998.Clin. Cancer Res. 4, 2463.
Legal Information
Disclaimer
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
相关内容
The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.
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