420101
JAK3 抑制剂 I
The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
JAK3 抑制剂 I, 4-（4ʹ-羟基苯基）氨基-6，7-二甲氧基喹唑啉，WHI-P131
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关于此项目
经验公式（希尔记法）:
C16H15N3O3
化学文摘社编号:
分子量:
297.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N(c3ccc(cc3)O)c1ncnc2c1cc(c(c2)OC)OC
InChI
1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
InChI key
HOZUXBLMYUPGPZ-UHFFFAOYSA-N
General description
JAK3的细胞可渗透，可逆，有效，ATP竞争性和特异性抑制剂（Janus家族激酶3；IC50 = 78 µM）。对JAK1，JAK2或ZAP/Syk或Src酪氨酸激酶没有效应。作为胶质母细胞瘤细胞粘连和迁移的有效抑制剂。还报告了阻断凝血酶诱导的血小板聚集。
Biochem/physiol Actions
主要靶标
Janus家族激酶3
Janus家族激酶3
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：78 µM，针对Janus家族激酶3
Packaging
用惰性气体包装
Other Notes
Tibbles, H.E., et al. 2001.J. Biol. Chem.276, 17815.
Sudbeck, E.A., et al. 1999.Clin. Cancer Res.5, 1569.
Goodman, P.A., et al. 1998.J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998.Clin. Cancer Res. 4, 2463.
Sudbeck, E.A., et al. 1999.Clin. Cancer Res.5, 1569.
Goodman, P.A., et al. 1998.J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998.Clin. Cancer Res. 4, 2463.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable