420127
Jasplakinolide
from Jaspis johnstoni, ≥90% (HPLC), liquid, Actin polymerization promotor, Calbiochem
别名:
InSolution Jasplakinolide，Jaspis johnstoni, InSolution Jasplakinolide, Jaspis johnstoni
产品名称
Jasplakinolide，来源于Jaspis johnstoni, InSolution, ≥90%, 1 mM in DMSO, mammablian cell mitosis inhibitor, potent inducer of actin polymerization and stabilization
assay
≥90% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
细胞可渗透的F-肌动蛋白探针。从海洋海绵Jaspis johnstoni中分离出的这种大环环缩肽是体外肌动蛋白聚合和稳定的有效诱导剂。它与鬼笔环肽（目录编号516640）竞争肌动蛋白结合（Kd=15 nM），并增强白介素2（IL-2）剥夺诱导的凋亡。还具有杀菌、杀虫和抗癌特性。
Biochem/physiol Actions
主要靶标
F-肌动蛋白
F-肌动蛋白
产物不与ATP竞争。
可逆：否
对于肌动蛋白结合，Kd=15 nM
细胞渗透性：否
Packaging
用惰性气体包装
Physical form
Jasplakinolide，Jaspis johnstoni（目录编号420107）在DMSO中的1 mM（50 µg/71 µl）溶液。
Preparation Note
初次融化后，等分并冷冻（-20°C）。
Other Notes
Rosado, J.A., et al. 2000.J. Biol. Chem.275, 7527.
Posey, S.C., and Bierer, B.E.1999.J. Biol. Chem.274, 4259.
Senderowicz, A.M., et al. 1995.J. Natl.Cancer Inst.87, 46.
Bubb, M.R., et al. 1994.J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988.Antimicrob.Agents Chemother.32, 1154.
Posey, S.C., and Bierer, B.E.1999.J. Biol. Chem.274, 4259.
Senderowicz, A.M., et al. 1995.J. Natl.Cancer Inst.87, 46.
Bubb, M.R., et al. 1994.J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988.Antimicrob.Agents Chemother.32, 1154.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害（C）
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
法规信息
低风险生物材料
此项目有
Kelli L Hvorecny et al.
Nature communications, 15(1), 1840-1840 (2024-02-29)
The cytoskeletal protein actin plays a critical role in the pathogenicity of the intracellular parasite, Toxoplasma gondii, mediating invasion and egress, cargo transport, and organelle inheritance. Advances in live cell imaging have revealed extensive filamentous actin networks in the Apicomplexan
Evdokiia Potolitsyna et al.
Communications biology, 7(1), 458-458 (2024-04-16)
Differentiation of adipose progenitor cells into mature adipocytes entails a dramatic reorganization of the cellular architecture to accommodate lipid storage into cytoplasmic lipid droplets. Lipid droplets occupy most of the adipocyte volume, compressing the nucleus beneath the plasma membrane. How
Kem A Sochacki et al.
Developmental cell, 56(8), 1131-1146 (2021-04-07)
Clathrin-mediated endocytosis is the primary pathway for receptor and cargo internalization in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding membranes. The mechanism and control of lattice assembly, curvature, and vesicle formation at the plasma
Anna M Koester et al.
Biomolecules, 12(8) (2022-07-28)
Recent work suggests that Ras small GTPases interact with the anionic lipid phosphatidylserine (PS) in an isoform-specific manner, with direct implications for their biological functions. Studies on PS-Ras associations in cells, however, have relied on immuno-EM imaging of membrane sheets.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持