420135
JNK Inhibitor VIII
The JNK Inhibitor VIII, also referenced under CAS 894804-07-0, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
JNK Inhibitor VIII, N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H20N4O4
化学文摘社编号:
分子量:
356.38
MDL number:
UNSPSC Code:
41116133
NACRES:
NA.77
产品名称
JNK Inhibitor VIII, The JNK Inhibitor VIII, also referenced under CAS 894804-07-0, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
SMILES string
N(c2nc(c(c(c2)N)C#N)OCC)C(=O)Cc1c(ccc(c1)OC)OC
InChI
1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
InChI key
KQMPRSZTUSSXND-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
brown
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.
Other Notes
Vivanco, I., et al. 2007. Cancer Cell11, 555.
Szczepankiewicz, B. G., et al. 2006. J. Med. Chem.49, 3563.
Szczepankiewicz, B. G., et al. 2006. J. Med. Chem.49, 3563.
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持