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Merck
CN

420141

JAK2 Inhibitor V, Z3

The JAK2 Inhibitor V, Z3, also referenced under CAS 195371-52-9, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

JAK2 Inhibitor V, Z3, 2-Methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one

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关于此项目

经验公式（希尔记法）:
C23H24N2O
化学文摘社编号:
195371-52-9
分子量:
344.45
UNSPSC Code:
12352200

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InChI key

SETYDCSRABYHSW-UHFFFAOYSA-N

InChI

1S/C23H24N2O/c1-23(15-13-20-11-5-7-17-24-20,16-14-21-12-6-8-18-25-21)22(26)19-9-3-2-4-10-19/h2-12,17-18H,13-16H2,1H3

assay

≥97% (HPLC)

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

colorless

solubility

DMSO: 10 mg/mL, ethanol: 10 mg/mL

shipped in

wet ice

Quality Level

100

General description

A cell-permeable pyridinylbutanone compound that inhibits cellular autophosphorylation of both the wild-type Jak2 and the constitutively active V167F mutant (IC50 = 15 & 28 µM, respectively, with WT- & V617F-transfected BSC-40 cells), while exhiting no effect against cellular Tyk2 autophosphorylation in COS cells or c-Src kinase in cell-free kinase assays. Z3 suppresses the Jak2-V167F-dependent proliferation of the erythroleukemia cell line HEL by blocking the G1-S transition and is shown to effectively reduce the cytokine-stimulated growth of both Jak2-V617F-positive and Jak2-F537I-positive primary hematopoietic progenitor cells from myeloproliferative disorder patients.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sayyah, J., et al. 2008. Mol. Cancer Ther.7, 2308.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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相关内容

JAK/STAT Signaling Research Focus

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.

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