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Merck
CN

420294

STAT5 Inhibitor II, IQDMA

The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.

别名:

STAT5 Inhibitor II, IQDMA, N1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine

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关于此项目

经验公式（希尔记法）:
C19H20N4
分子量:
304.39
NACRES:
NA.77
UNSPSC Code:
12352200

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产品名称

STAT5 Inhibitor II, IQDMA, The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

brown

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.

Other Notes

Su, J.C., et al. 2009, Life Sci.85, 505.
Chien, C.M., et al. 2008, Chem-Biol. Intr.176, 40.
Yang, S.H., et al. 2008, J. Biochem. Mol. Tox.22, 396.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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