420320
KT5720
≥95% (HPLC), solid, protein kinase A inhibitor, Calbiochem®
别名:
KT5720
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C32H31N3O5
化学文摘社编号:
分子量:
537.61
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
产品名称
KT5720, A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a.
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CNC7=O)cccc6)[C@H]5O[C@@]1([C@](C5)(O)C(=O)OCCCCCC)C
InChI
1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1
InChI key
ZHEHVZXPFVXKEY-RUAOOFDTSA-N
General description
一种有效、特异性、细胞渗透性、可逆性和ATP竞争性的蛋白激酶A（Ki=56 nM）抑制剂，通过化学修饰K-252a制备。不会显著影响PKC、PKG和MLCK的活性。抑制培养的神经元中的轴突分支。也可购买2 mM（50 µg/47 µl）KT 5720（目录号420323)）在DMSO中的溶液。
通过K-252a的化学修饰制备。一种有效、特异性、细胞可渗透性、可逆和ATP竞争性的蛋白激酶A（Ki=56 nM）抑制剂。不会显著影响PKC、PKG或MLCK的活性。抑制培养的神经元中的轴突分支。
Biochem/physiol Actions
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标Ki：56 nM，对于蛋白激酶A
首要靶标
PKA
PKA
Preparation Note
仅在使用前再用水相缓冲液进行稀释。
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
Other Notes
Simpson, C.S., and Morris, B.J.1995.Neuroscience 68, 97.
Cabell, L., and Audesirk, G. 1993.Int. J. Dev.Neurosci.11, 357.
Gadbois, D.M., et al. 1992.Proc.Natl.Acad.Sci. USA89, 8626.
Kase, H., et al. 1987.Biochem.Biophys.Res. Commun.142, 436.
Cabell, L., and Audesirk, G. 1993.Int. J. Dev.Neurosci.11, 357.
Gadbois, D.M., et al. 1992.Proc.Natl.Acad.Sci. USA89, 8626.
Kase, H., et al. 1987.Biochem.Biophys.Res. Commun.142, 436.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
Still not finding the right product?
Explore all of our products under KT5720
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Lay Teng Ang et al.
Cell, 185(14), 2523-2541 (2022-06-24)
Stem cell research endeavors to generate specific subtypes of classically defined "cell types." Here, we generate >90% pure human artery or vein endothelial cells from pluripotent stem cells within 3-4 days. We specified artery cells by inhibiting vein-specifying signals and vice
Kyohei Tokizane et al.
Glia, 65(5), 740-755 (2017-02-10)
Under a quiescent state, microglia exhibit a ramified shape, rather than the amoeboid-like morphology following injury or inflammation. The manipulation of microglial morphology in vitro has not been very successful, which has impeded the progress of microglial studies. We demonstrate
Tomomi Kurashige et al.
Journal of the Endocrine Society, 4(7), bvaa054-bvaa054 (2020-07-17)
Autophagy is an evolutionarily conserved catabolic process by which cells degrade intracellular proteins and organelles in the lysosomes and recycle their metabolites. We have recently demonstrated the crucial role for the basal level of autophagic activity in thyrocyte survival and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 420320-100UG | 04055977211023 |
| 420320-50UG | 04055977211030 |