420321
KT5823
≥98% (HPLC), Protein Kinase G inhibitor, solid
别名:
KT5823, PKG Inhibitor VII
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关于此项目
经验公式（希尔记法）:
C29H25N3O5
化学文摘社编号:
分子量:
495.53
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
KT5823, Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM).
SMILES string
[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CN(C7=O)C)cccc6)[C@@H]5O[C@]1([C@@](C5)(OC)C(=O)OC)C
InChI
1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
InChI key
QTYMDECKVKSGSM-YMUMJAELSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 1 mg/mL
DMF: soluble
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKG
PKG
Product competes with ATP.
Reversible: yes
Target Ki: 234 nM against protein kinase G
Disclaimer
Toxicity: Standard Handling (A)
General description
Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). Inhibits protein kinase C (Ki = 4.0 µM) and protein kinase A (Ki >10.0 µM) at higher concentrations.
Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM).
Other Notes
Grider, J.R. 1993. Am. J. Physiol.264, G334.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Further dilute with aqueous buffers just prior to use.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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