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Merck
CN

420323

KT5720

InSolution, ≥95%

别名:

InSolution KT5720, PKA Inhibitor VII

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关于此项目

经验公式（希尔记法）:
C32H31N3O5
化学文摘社编号:
108068-98-0
分子量:
537.61
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00132118

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SMILES string

[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CNC7=O)cccc6)[C@H]5O[C@@]1([C@](C5)(O)C(=O)OCCCCCC)C

InChI

1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1

InChI key

ZHEHVZXPFVXKEY-RUAOOFDTSA-N

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

solubility

DMSO: soluble

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

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相关类别

Biochem/physiol Actions

Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 56 nM against protein kinase A

Packaging

Packaged under inert gas

Physical form

A 2 mM (50 µg/47 µl) solution of KT 5720 (Cat. No. 420320) in DMSO.

Preparation Note

Following the initial thaw, aliquot and freeze (20°C).

Other Notes

Simpson, C.S., and Morris, B.J. 1995. Neurosci.68, 97.
Cabell, L, and Audesirk, G. 1993. Int. J. Dev. Neurosci.11, 357.
Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA89, 8626.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun.142, 436.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - (refers to pure substance)

flash_point_c

87 °C - (refers to pure substance)

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Ilse Delint-Ramirez et al.
Molecular cell, 82(20), 3794-3809 (2022-10-08)
Neuronal activity induces topoisomerase IIβ (Top2B) to generate DNA double-strand breaks (DSBs) within the promoters of neuronal early response genes (ERGs) and facilitate their transcription, and yet, the mechanisms that control Top2B-mediated DSB formation are unknown. Here, we report that

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