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420323

KT5720

Name: KT5720
Brand: MM

InSolution, ≥95%

别名:

InSolution KT5720, PKA Inhibitor VII

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关于此项目

经验公式（希尔记法）:

C₃₂H₃₁N₃O₅

化学文摘社编号:

108068-98-0

分子量:

537.61

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00132118

Assay:

≥95% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

Quality Level

100

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

solubility

DMSO: soluble

shipped in

wet ice

storage temp.

−20°C

SMILES string

[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CNC7=O)cccc6)[C@H]5O[C@@]1([C@](C5)(O)C(=O)OCCCCCC)C

InChI

1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1

InChI key

ZHEHVZXPFVXKEY-RUAOOFDTSA-N

说明

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target K_i: 56 nM against protein kinase A

Packaging

Packaged under inert gas

Physical form

A 2 mM (50 µg/47 µl) solution of KT 5720 (Cat. No. 420320) in DMSO.

Preparation Note

Following the initial thaw, aliquot and freeze (20°C).

Other Notes

Simpson, C.S., and Morris, B.J. 1995. Neurosci.68, 97.
Cabell, L, and Audesirk, G. 1993. Int. J. Dev. Neurosci.11, 357.
Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA89, 8626.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun.142, 436.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - (refers to pure substance)

flash_point_c

87 °C - (refers to pure substance)

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Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks.

Ilse Delint-Ramirez et al.

Molecular cell, 82(20), 3794-3809 (2022-10-08)

Neuronal activity induces topoisomerase IIβ (Top2B) to generate DNA double-strand breaks (DSBs) within the promoters of neuronal early response genes (ERGs) and facilitate their transcription, and yet, the mechanisms that control Top2B-mediated DSB formation are unknown. Here, we report that

全球贸易项目编号

货号	GTIN
420323-50UG	04055977210651