421050
(Z-LL)2 Ketone
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases.
别名:
(Z-LL)2 Ketone, 1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Processing of the p-Prl signal peptide
Processing of the p-Prl signal peptide
Product does not compete with ATP.
Reversible: no
Target IC50: ~ 50 nM inhibiting the processing of the p-Prl signal peptide
Packaging
Packaged under inert gas
Analysis Note
single spot by TLC
Other Notes
Weihofen, A., et al. 2002. Science296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Z-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Youngkyung Cho et al.
BMC biology, 18(1), 60-60 (2020-06-05)
Epithin/PRSS14, a type II transmembrane serine protease, is an emerging target of cancer therapy because of its critical roles in tumor progression and metastasis. In many circumstances, the protease, through its ectodomain shedding, exists as a soluble form and performs
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