422500
几夫碱，Kitasatosporia kifunense
A potent alkaloid inhibitor of mannosidase I.
别名:
几夫碱，Kitasatosporia kifunense
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关于此项目
经验公式（希尔记法）:
C8H12N2O6
化学文摘社编号:
分子量:
232.19
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
N21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O
InChI
1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
InChI key
OIURYJWYVIAOCW-PQMKYFCFSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
hot water: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
甘露糖苷酶I的强效生物碱抑制剂。甘露糖苷酶II和内质网α-甘露糖苷酶的无效抑制剂。
Biochem/physiol Actions
主要靶标
甘露糖苷酶-1
甘露糖苷酶-1
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Other Notes
Weng, S., and Spiro, R.G.1996.Arch.Biochem.Biophys.325, 113.
Kayakiri, H., et al. 1991.Chem. Pharm. Bull.39, 1378.
Elbein, A.D., et al. 1990.J. Biol. Chem. 265, 15599.
Iwami, M., et al. 1987.J. Antibiotic.40, 612.
Kayakiri, H., et al. 1991.Chem. Pharm. Bull.39, 1378.
Elbein, A.D., et al. 1990.J. Biol. Chem. 265, 15599.
Iwami, M., et al. 1987.J. Antibiotic.40, 612.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Merve Sen et al.
Biomolecules, 11(10) (2021-10-24)
Rhodopsin (RHO) misfolding mutations are a common cause of the blinding disease autosomal dominant retinitis pigmentosa (adRP). The most prevalent mutation, RHOP23H, results in its misfolding and retention in the endoplasmic reticulum (ER). Under homeostatic conditions, misfolded proteins are selectively
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