422625
KLF5 Inhibitor, CID 5951923
The KLF5 Inhibitor, CID 5951923 controls the biological activity of KLF5.
别名:
KLF5 Inhibitor, CID 5951923, 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate
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关于此项目
经验公式（希尔记法）:
C16H18N2O7S
化学文摘社编号:
分子量:
382.39
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
SMILES string
[S]1(=O)(=O)CC(CC1)N(C)C(=O)COC(=O)\C=C\c2cc(ccc2)[N+](=O)[O-]
InChI
1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+
InChI key
URVRJYLSUVXWBC-AATRIKPKSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.
Other Notes
Bialkowska, A., et al. 2011. Mol. Cancer Ther.10, 2043.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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