422689
Kir2.1 Inhibitor, ML133
The Kir2.1 Inhibitor, ML133, also referenced under CAS 185669-79-8, controls the biological activity of Kir2.1. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Kir2.1 Inhibitor, ML133, Inward rectifier potassium channel blocker, ML133
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关于此项目
经验公式（希尔记法）:
C19H19NO
化学文摘社编号:
分子量:
277.36
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
InChI
1S/C19H19NO/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17/h2-12,20H,13-14H2,1H3
SMILES string
COC(C=C1)=CC=C1CNCC2=C(C=CC=C3)C3=CC=C2
InChI key
GIFYKGIODMXYNT-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mg/mL, clear, colorless
shipped in
ambient
Quality Level
General description
A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 >300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lindsley, C.W., et al. 2011. ACS Chem. Biol.6, 845.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1.
Ruddiman, et al.
JCI insight, 8 (2023)
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