422706
KN-62
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme.
别名:
KN-62, 1-[N,O- bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II, 1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II
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关于此项目
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
off-white
solubility
methanol: 5 mg/mL, DMSO: soluble
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3
InChI key
RJVLFQBBRSMWHX-UHFFFAOYSA-N
General description
A cell-permeable, reversible, and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 900 nM for rat brain enzyme) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cam kinase 2
cam kinase 2
Product does not compete with ATP.
Reversible: yes
Target Ki: 900 nM for rat brain CaM kinase II
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Further dilute with aqueous buffer just prior to use.
Other Notes
Minami, H., et al. 1994. Biochem. Biophys. Res. Commun.199, 241.
Kato, M., et al. 1992. Neurosci. Lett.129, 47.
Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun.176, 1051.
Ito, I., et al. 1991. Neurosci. Lett.121, 119.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.
Kato, M., et al. 1992. Neurosci. Lett.129, 47.
Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun.176, 1051.
Ito, I., et al. 1991. Neurosci. Lett.121, 119.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable